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GHK binds copper because of a specific combination of functional groups that together form a high-affinity copper-coordination site: the N-terminal amine donates one nitrogen ligand, the histidine imidazole donates a second nitrogen ligand, and the deprotonated amide nitrogen of the Gly-His peptide bond donates a third nitrogen ligand

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Titrate: Move to 200 mg per dose (100 units, 1.0 mL) from week 3 onward as tolerated

A key pathway that maintains cellular glutathione levels and the ability of the cell to adapt to stress is called Keap1-Nrf2

Theoretically, any process that increases iron absorption, reduces iron storage, or restricts iron efflux can raise intracellular free iron levels and induce ferroptosis