To meet the diagnostic criteria for pEDS, a person must meet: Major criterion 1 AND two other major criteria AND one minor criterion OR Major criterion 2 AND two other major criteria AND one minor criterion Major Criteria Severe and intractable periodontitis of early onset (childhood or adolescence) Lack of attached gingiva Pretibial plaques Family history of a first-degree relative who meets the clinical diagnostic criteria for pEDS Minor Criteria Easy bruising Joint hypermobility, mostly distal joints Skin hyperextensibility and fragility, abnormal scarring (wide or atrophic) Increased rate of infections Hernias Marfanoid facial features Acrogeria Prominent vasculature Spondylodysplastic EDS (spEDS) If a person meets the diagnostic criteria for spEDS, genetic testing should be done to confirm the diagnosis
We performed both operations without removing or replacing the intrathecal catheter, taking care not to damage the intrathecal catheter or spinal cord
Involvement of opioid system and TRPM8/TRPA1 channels in the antinociceptive effect of Spirulina platensis
PMID: 22893199 Eikelboom JW et al (2012): Antiplatelet Drugs
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