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This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment

The shelf life drops from months to weeks

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

Understanding these biological rhythms is fundamental to developing an optimal dosing strategy

However, personalized dosage based on lab results is essential