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Contaminants including residual solvents, heavy metals, and bacterial endotoxins require testing beyond simple purity assessment

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However, 15% to 20% of ER+ tumors are intrinsically resistant to endocrine treatment while 30% to 40% of ER+ tumors develop endocrine resistance to this class of drugs throughout treatment [9, 10]

doi: 10.1093/geronj/11.3.298