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In colon biopsy samples from IBD patients, CD4 + T cells show markedly increased pyruvate dehydrogenase kinase (PDK) expression, and PDK4 inhibition alleviates intestinal inflammation in a DSS-induced murine colitis model (210)

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Research on oxidative stress during exercise has begun to indicate that regular training enhances the ability of these mechanisms to effective respond to the increase of oxidative product