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It downregulates inflammatory mediators such as IL-6, indirectly modulating hepc activity and restoring iron homeostasis (87, 88)

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At a further level of complexity, many nanoplatforms are also engineered to interact with defined immune cell populations or signaling pathways, with the aim of partially relieving immunosuppressive features of the tumor microenvironment and creating conditions more permissive for systemic immunotherapy or rational combination regimens [9, 29, 35]

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