Its primary characterized mechanisms include upregulation of growth factor receptors (VEGFR2, EGFR), promotion of angiogenesis through FAK-paxillin pathway activation, and modulation of nitric oxide synthesis
Oct 21 2020;21(20)doi:10.3390/ijms21207796
However, biodistribution and tissue retention effects reported in preclinical studies imply that functional/biological effects can persist longer than plasma exposure alone would predict
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