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Peer review Peer review information Nature Reviews Cardiology thanks Peter Rossing, Geoff Werstuck and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

However, an important role Eph/ephrins system has also been found in pathological conditions such as cancer [158, 159]

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It was found through preliminary research that treatment with AOD9604 over the course of 14 days in obese mice led to decreased body weight and body fat and was shown to increase the activity of the beta(3)-adrenergic receptors in the fat cells to the same level as those in lean mice