To eradicate LSCs, researchers are exploring the field of metabolism to find metabolic differences between LSCs and their healthy counterparts
317 BBB vascular repair and remodelling Guidance molecules including netrins, ephrins, semaphorins and Nogo-A that regulate CNS angiogenesis have also been described to improve BBB integrity by regulating the maturation of the brain ECs, recruitment of pericytes and restoration of tight junctions in ischaemic stroke models
Safety concerns arise with overthecounter peptide purchases: lack of FDA approval, purity, and potential immunogenicity
To determine the optimal experimental time point for barrier maturity, transepithelial electrical resistance (TEER) was monitored at several intervals (days 7, 14, 21, 24, and 25)