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578 , 908 , 909 The incremental fiveyear cost of care for dementia paid by Medicare has been estimated at nearly $16,000 per person in 2017 dollars ($19,501 in 2025 dollars), with nearly half of these costs incurred in the year after diagnosis and 87% concentrated in the two years after diagnosis

Neuron 63 , 628642 (2009)

Upregulation of the mitochondrial calcium uniporter (MCU) contributes to calpain/OPA-1-mediated inhibition of mitophagy, suppressing excessive apoptosis through OPA1 [99]

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Size of nanoparticles Nanoparticles are attractive because their small size can enable passage across highly selective barriers such as the blood brain barrier (BBB)