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442 Preclinical studies have documented the inhibitory effects of GLP-1RAs on the development of AS in animal models

These lesions range from fibrotic changes in autopsy findings to severe forms of fibrosing organizing pneumonia

Currently, it is believed that dietary ingredients with anti-proliferative, anti-inflammatory, antioxidant, analgesic, and estrogen-reducing properties can reduce the incidence of endometriosis

These agents are investigational or research use in many settings and are not approved for general clinical use

Future Direction and Call to Action The current evidence gap presents an opportunity for orthopaedic investigators to establish high-quality prospective registries evaluating peptide exposure in real-world musculoskeletal populations