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The standard protocol involves 5 to 10 mg daily via subcutaneous injection for 10 to 20 consecutive days, repeated once or twice per year with 4 to 6 months between cycles

Since there is no known hazardous threshold for vitamin B12, there is no upper limit

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While a two-year clinical trial using 300 mg per day did not show major changes in nerve function, shorter studies lasting 3 to 12 weeks found that higher doses, up to 600 mg daily, improved symptoms in people with diabetic neuropathy

High Vitamin B12 Blood Levels and Diseases Sometimes high blood levels can be attributed to serious diseases