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However, in the only available human study on trained athletes, this substrate shift appeared maladaptive: the Meldonium group showed a lower VO max and workload alongside an increased RER, suggesting impairedor at least not improvedmaximal performance (59)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Zhao M., Mei T., Shang B., Zou B., Lian Q., Xu W., Wu K., Lai Y., Liu C., Wei L., et al