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Higdon J, Drake VJ, Delage B, Johnson EJ (2023c) Carotenoids, Phytochemicals, Linus Pauling Institute, Oregon 2023, Accessed Nov 18, 2023

In some cases, steroid injections or surgery may be advised

[Studies of gamma-oryzanol

Targeting just one pathway produces significant results

Moreover, a recent randomized crossover study in healthy women demonstrated that prolonged mild sleep restriction markedly increased endothelial oxidative stress without activating compensatory antioxidant responses, due to reduced expression of DCUN1D3 gene, a regulator of the Nrf2-mediated antioxidant pathway, thereby suggesting a mechanistic link between insufficient sleep and vascular oxidative injury 78