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In addition, in the cecum of cefoperazone-treated mice, the existence of C

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The interaction of these cytokines, immune modulators, and signaling pathways triggers a series of events in the synovium, eventually leading to joint damage [21, 22] The main targets that are essential in the molecular pathways involved in the development of RA are TNF, IL, JAK, GM-CSF, MAPK, PI-3 K/AKT/mTOR, and BTK (Tables 1 and 2) (Fig