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The most well-established among them appears to be nuclear factor erythroid 2-related factor 2 (Nrf2), which is likely activated by redox status changes of the kelch-like ECH associated protein 1 (Keap1) induced by NAPQI

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doi: 10.1038/nature18930 [DOI] [PMC free article] [PubMed] [Google Scholar] 47

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