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It has been shown that mitochondria-free axon terminals of hippocampal or cortical neurons accumulate more Ca 2+ in response to repetitive stimulation, which promotes increasingly more SV release [55, 56]

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Role of CGRP in neuroimmune interaction via NF-B signaling genes in glial cells of trigeminal ganglia

These findings, in line with several recent studies reporting the protective effects of statins in various kidney diseases [42,43,44,45], underscore the critical role of lipid metabolic dysregulation in CaOx-induced renal injury and suggest that pharmacological modulation of lipid metabolism may serve as a complementary strategy to targeting the PRMT1/UBE2m axis

The response is cumulative, building across the 4 doses and continuing into the weeks after the final injection