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3.2.2 Increasing Sensitivity to TAM and Reducing Resistance TAM is an endocrine drug that is most commonly used to block the effects of estrogen at all stages of breast cancer, especially in postmenopausal patients

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Episodes generally occur several times a year but can happen up to once or twice a month

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The same stimulus can induce distinct forms of cell death depending on the specific situation

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A first mechanism is the direct interaction with the reducing thiolate, leading to irreversible inactivation of the active site, as described for the inactivation of GSTs (Scheme 9)

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