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Oxidative stress, disturbed calcium homeostasis, and metabolic stress lead to the accumulation of misfolded proteins, triggering UPRER, while ROS and Ca 2+ signaling from damaged mitochondria exacerbate this burden

The main focus is on the two most common neurodegenerative diseases, Alzheimers disease and Parkinsons disease, other neurodegenerative diseases are also involved in a small amount

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Overbey also won the 100 breaststroke in 1:05.51