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Transamination also decreases urea formation and prevents uremic toxin buildup

Lactate-mediated PHD2 damage relies on the oxidation of lactate to pyruvate, which elicits suppression of PHD2 through pyruvate binding, alongside HIF-1-mediated elevation of VEGF

To the best of our knowledge, human pharmacokinetic studies of a pine bark extract have been only reported for Pycnogenol