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The Obesity Medicine Associations 2023 clinical guidelines do not list B12 or MIC shots among evidence-based pharmacotherapies for obesity

Common B12 Deficiency Symptoms: Persistent brain fog and cognitive decline affecting daily performance Chronic fatigue unrelieved by rest or lifestyle modifications Migraines and neurological symptoms including neuropathy Depression , anxiety, and seasonal affective disorder Memory loss and increased risk of dementia and Alzheimers Digestive issues and compromised immune system function Infertility and reproductive health complications Medical Conditions and Risk Factors Numerous medical conditions significantly increase the risk of B12 deficiency by interfering with absorption, utilization, or storage of this essential vitamin

doi: 10.1038/s41392-020-00312-6 123 HoeselBSchmidJA

However, the AREDS2 formula uses 400 IU, which is higher than typical daily needs but has been proven safe for eye health

On the other hand, an occasional dose of biotin might help whenever patients notice damaged or dull hair.