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As cells divide, these telomeres gradually shorten, leading to cellular aging and eventual cell death

This mechanism involves reducing cyclic adenosine monophosphate (AMP) accumulation and preventing CREB-mediated transcription of gluconeogenic genes, leading to reduced glucose 6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase 1 (Pck1) expression (He et al., 2009

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Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone