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PMID: 29211849

The Role of Melanin in Skin Pigmentation Melanin serves as the body's natural defense mechanism against harmful ultraviolet radiation, but when melanin production becomes dysregulated, it leads to visible pigmentation problems

supplementing them back toward youthful levels is the rationale for long-term use

The wrinkles, the thinning, the loss of density and resilience that we associate with aging skin are not entirely inevitable they're partly the consequence of losing this molecule

The declining plasma concentration provides a quantitative framework for researchers designing dose-response studies, as physiologically relevant in vitro concentrations should bracket the 200-500 nM range to model the young-to-aged spectrum