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[PubMed: 21211533] 20

Both insulin and IGF-1 can bind to and activate each others receptors, albeit with reduced affinity [12]

Arbutin: A natural skin brightener that reduces the appearance of dark spots and hyperpigmentation

304,305,306 This is consistent with clinical analysis that a strong correlation between PGC-1 expression and the formation of distant metastases exists in invasive cancer cells