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Honeys antioxidant activity is largely owed to its abundant polyphenol and flavonoid content through three synergistic mechanisms: (i) neutralization of reactive oxygen species (ROS), (ii) upregulation of several antioxidant enzymesincluding SOD, GR, GPx, and CAT, and (iii) transcriptional regulation of genes involved in redox balance (114, 115)

Antioxidant therapy and Down syndrome Since oxidative stress is one of the most important neuropathological processes contributing to cognitive deficits in Down syndrome

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[11] Engelstein D, Mukamel E, Cytron S, et al

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