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Prostaglandins have been used topically to stimulate melanogenesis, while Melitane, a biomimetic peptide that activates the melanocortin one receptor, has shown promise in promoting hair pigmentation

The whole process of follicular development is accompanied by the continuous proliferation of granulosa cells, and the steroid hormones synthesized and secreted by granulosa cells and theca cells further stimulate the development of follicles 50

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Simply put, most products do not effectively absorb into the cells