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Source: NCBI 9.3 Million In 2020, 3.3 percent (about 9.3 million individuals) reported misusing prescription pain drugs in the past 12 months

Aquilariae Lignum fraction pretreatment of LPS-stimulated BV2 microglia cells significantly reduced NO, cyclooxygenase-2 (COX-2), IL-1, and prostaglandin E2 levels and attenuated nuclear factor-kappaB (NF-B) and p65 activities [109]

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