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In the liver, although both increased FFA uptake and upregulated de novo lipogenesis contribute to the development of hepatic steatosis, accumulating evidence suggests that increased FFA uptake plays a predominant role in the development of fatty livers 1

Mechanistically, it activates Nrf2 and its nuclear translocation, thereby enhancing the expression of downstream antioxidant genes to relieve oxidative stress

Participants took part in both trials, one week apart, receiving either a ketone ester drink or an isocaloric control drink in a randomized order

The coxsackievirus B 3Cpro protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling

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