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Toxicological findings consistently indicate size- and shape-dependent uptake and effects: smaller particles exhibit greater cellular internalisation, reactivity, and biodistribution, with predominant oxidative, inflammatory, metabolic, and genotoxic responses, whereas larger microplastics more often provoke mechanical irritation

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When these complexes are damaged by lipid peroxidation (the oxidative degradation of lipids in the mitochondrial membrane), ATP production grinds to a halt

While some individuals may notice subtle improvements in appetite, sleep, or energy shortly after starting treatment, most benefits develop gradually over time as the body responds to the peptides signaling effects

10.1186/s40168-020-00914-w Microbiome 31 DalileB.Van OudenhoveL.VervlietB.VerbekeK