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It may have to do with inflammation, oxidative stress, and autoimmunity.(6) Gluten sensitivity

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TKT, as part of the cytosolic pentose phosphate pathway, along with the mitochondrial multienzyme complexes of pyruvate (PDHC) and 2-oxoglutarate dehydrogenases (OGDHC), are essential for energy production from glucose oxidation

This creates constant energy demand, leading to a massive influx of oxygen and the production of reactive oxygen species (ROS) that can damage the very cellular machinery that powers the cell

Cell Mol Life Sci 75(18):33133327