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Most patients are diagnosed in the middle to late stages of the illness, when irreversible brain damage has already occurred and interventions to prevent the disease are less likely to be successful ( The implementation of a combination of biomarker tests, that includes imaging measures of BBB dysfunction, could aid in early diagnosis, in monitoring disease progression and in evaluating treatment response to new drugs (Figure 2C summarizes the main processes driving BBB disruption, the key factors involved and the role of BBB imaging in AD

On that test, an NNMT inhibitor plus an NAD+ precursor is at least internally coherent one addresses the drain, the other the supply while pairing 5-Amino-1MQ with an unrelated appetite-acting compound is not synergy, it is simply two separate interventions being run at once