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An ASD-unrelated study of neuronal dysregulation via Niemann-Pick type C1 (NPC1) deficiency revealed that imbalanced glutamine/glutamate metabolism accompanying folate metabolism disturbances in cerebellum neurons is correlated with widespread DNA methylation defects in the genome [178]

It plays a particularly important role in regulating oxidative stress which, when left unchecked, can interfere with deep, restorative sleep

10.3390/cells10102595 Summary Keywords fibromyalgia, oxidative stress, mitochondrial dysfunction, redox imbalance, neuroinflammation Citation Ho T, Ryan M and Holle J (2025) Redox reactions in chronic pain: mechanisms and relevance in fibromyalgia

Naur et al., 2003)