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This crosstalk has so far not been investigated

In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells

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Clin Pharmacokinet 2017;56:81523

The confluent coverslips were then aseptically transferred to new six well plates containing 900 l serum free DMEM