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However, not all xenobiotics (including drugs) are conjugated/inactivated by this pathway ( The mercapturic acid pathway ( Figure 1 ) involves the conjugation of the tripeptide, GSH, to xenobiotics (including drugs) to render them more hydrophilic and facilitate their elimination
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RTqPCR mRNA measurement After sacrificing the animals 1 and 24 hr after reperfusion, brain tissue, that is, the hippocampus, was rapidly dissected and frozen in liquid nitrogen
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Common triggers include: Sun exposure (the biggest factor) Hormonal changes (pregnancy, birth control, hormone therapy) Genetics Heat and inflammation Unlike simple sunspots, melasma is often symmetrical and chronic, meaning it can come back even after treatment
