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10.1016/S1002-0160(08)60039-9 149 YabutaY.MotokiT.YoshimuraK.TakedaT.IshikawaT.ShigeokaS

However, the effect of C677T polymorphisms of MTHFR on cognitive function was not significant in normal subjects as a longitudinal cognitive study showed that the MTHFR C677T polymorphism was not associated with cognitive performance at baseline or over 12 years 49

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However, no controlled human studies define optimal duration, maintenance dosing, or long-term exposure safety