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In some embodiments, the otic formulation or composition comprises between about 1% to about 3% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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(1) It can be used as an adjuvant therapy for chemotherapy (cisplatin, cyclophosphamide, doxorubicin, daunorubicin, bleomycin) to reduce chemotherapy-induced damage without affecting efficacy, thereby allowing for an increase in chemotherapy dosage

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