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Upon comparing the results from Supplementary Table S4, it was observed that the residues Asp-74, Glu-334, Tyr-341, His-447, Phe-295, and Phe-338 (as shown in Supplementary Figure S13) displayed significant movement in common among the 7 conformations, revealing changes in both the backbone and the side chain

, given in g- and ng-dose regimens in either stage of paracetamol intoxication)

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By crossing the blood-brain barrier, DSIP acts at the core of neural and systemic balance, enabling a multidimensional therapeutic impact ( 8, 9 )