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The total cell count, morphology, and the gene expression profile of iEANs in the duodenum, ileum, and colonic myenteric plexus varies significantly, with a higher neuronal count in specific-pathogen-free mice compared to germ-free animals (Matheis et al., 2020)

Mechanistically, GHK-Cu has been shown to stimulate collagen and elastin synthesis in dermal fibroblasts, increase decorin (a small proteoglycan that helps regulate collagen organization), and influence matrix metalloproteinases and their inhibitors

doi: 10.1016/j.bbamem.2012.12.012

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