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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.Nature Communications, 16(1), 5672

This action stimulates the immune system and exercises important immune defenses, helping to improve overall immunity, reverse autoimmune & allergy symptoms, combat mold illness, decrease heavy metal sensitivities, boost natural DAO production, eliminate histamine intolerance, and more, over time

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The shed eventually reverses and is generally considered a sign the treatment is working