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Clinical signs, especially in homozygous individuals, include nodular xanthomatosis, yellow papules on the trunk, arms and lower extremities, and retinal lipaemia

Ageing Res Rev 42:7285 Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK (2008) Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

While this is a welcome feature for bodybuilders, it can suppress testosterone production

Methylated forms of these vitamins are better absorbed, especially for kids with certain genetic mutations like MTHFR