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CLANs are interconnected networks of actin filaments that radiate outward from central hubs resembling a geodesic dome ( CLAN assembly, like fibronectin fibrillogenesis, also involves cooperativity between v3 integrin and a 1 integrin and is dependent on the level of v3 integrin expression and activity (Figure 1D)

For a broader foundation on how these molecules actually signal, How Peptides Work in the Body and 7 Types of Therapeutic Peptides cover the cell biology in accessible terms

Before staining, sections were treated with xylene and dehydrated with ethanol

Bourgeois JP, Rakic P (1993)

(2018), serves as a regulator for these ALMTs