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Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference

Multiple animal studies including post-infarction models show Thymosin Beta-4 reduces scar tissue formation, promotes cardiomyocyte survival, and supports microvascular regeneration in damaged heart tissue.22 A 2010 study published in Annals of the New York Academy of Sciences showed that Thymosin Beta-4 initiated adult cardiac progenitor cell differentiation and cardiac repair in injured myocardium.23 While direct long COVID RCT data doesn't yet exist for TB-500, the mechanistic overlap with long COVID cardiovascular pathology is strong

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