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Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics

[DOI] [PubMed] [Google Scholar] 341.Gayatri V., Krishna Prasad M., Mohandas S., Nagarajan S., Kumaran K., Ramkumar K.M

Epigenetic changes, telomere shortening and DNA damage, proteotoxicity, mitochondrial dysfunction, and changes in intercellular communication and key signaling pathways (MAPK, 176 JAK-STAT3, 177 and Notch 178 ) all lead to permanent cell cycle arrest and exhaustion of satellite cell pools

The fasting induced elevation in secretion of GH is blunted in obesity (516,517)

There are differences in practice between countries, with Canada and Sweden favoring use of oral vitamin B 12