Metabolic changes favor the activity and heterogeneity of reactive astrocytes

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According to FDA labeling, no clinically meaningful differences in tirzepatide pharmacokinetics have been observed across all levels of renal function, including severe renal impairment and end-stage renal disease
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Koekkoek SK, Yamaguchi K, Milojkovic BA, Dortland BR, Ruigrok TJ, Maex R et al (2005)