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Induction of glucose transporter 1 expression through hypoxia-inducible factor 1alpha under hypoxic conditions in trophoblast-derived cells

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The transition from the lipid environment of the BBB endothelial cell membrane to the aqueous interstitial fluid of the brains extracellular space necessitates further consideration of a drug and its delivery vehicles physicochemical properties, including size, surface charge, shape, and molecular weight (Sykova and Nicholson, 2008