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48 TurnbullL.ToyofukuM.HynenA

The increase of Hcy under metformin is likely linked to perturbances to the metabolism of vitamin B12 and may be more evident in obese PCOS [6]

doi:10.1530/eje.0.1390552 Vittone, J., Blackman, M

Journal of Clinical Oncology , 29 (32), 42864293

Similarly, authors [3] of the first double-blind, randomized, placebo-controlled clinical trial of oral glutathione (GSH) supplementation performed in healthy adult humans concluded that despite the biochemical plausibility, optimal dose, recommended timing of administration and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione (GSH) concentrations following 4 weeks of oral (2 x 500mg daily) glutathione (GSH) supplementation