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J Biotechnol 300:5562 Baltic S et al (2024) The impact of six-week dihydrogen-Pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial

Another study adds to this one by showing that as the brain becomes resistant to insulin , it can't properly use glucose, something scientists believe contributes, first and foremost, to the cognitive impairment seen in people with diabetes

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Plateaus reflect receptor adaptation, not permanent medication failure

Limited Clinical Safety Data : The human safety profile remains unclear because the evidence is primarily based on animal and laboratory studies rather than large-scale clinical trials