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Treatment for depression is typically stratified by severity, with mild depression managed through psychoeducation, self-care, and psychotherapy, while moderate to severe depression often requires a combination of psychotherapy and antidepressant medications [496]

Thus, these cells can make part of the cardiac endothelium (ECs from the endocardium) and the vascular endothelium (ECs from the internal cellular layer of cardiac vessels) (Fig

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