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Identification of Key Amino Acids Responsible for the Substantially Higher Affinities of Human Type 1 3-Hydroxysteroid Dehydrogenase/isomerase (3-HSD1) for Substrates, Coenzymes, and Inhibitors Relative to Human 3-HSD2

Injectable administration is hypothesized to provide systemic distribution, but human pharmacokinetic data for this route does not exist

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Piya S, Bhattacharya S, Mu H, Lorenzi PL, McQueen T, Davis RE, Ruvolog V, Baran N, Qian Y, Crews C, Kantarjian HM, Andreeff M , Borthakur G

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