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In the imminent future, every patient may be able to get their complete genome and gut microbiome sequenced, as well as the gut metabolome data analyzed

The inclusion criteria stipulated that participants be healthy male and female non-smokers, aged 30-79 years, who had not taken antioxidant supplements for at least one month prior to enrollment

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The TCA product -ketoglutarate can be converted to glutamate, which is converted to glutamine by glutamine synthetase, an enzyme that is predominately, if not exclusively, located in astrocytes [20]

conducted a CRISPR/Cas9 genetic screen with KEAP1 -mutant lung cancer cells and found that NRF2-addicted cancer cells are highly dependent on glutamine uptake, and that, consequently, inhibition of glutamine-derived glutamate by glutaminase inhibition effectively suppresses NRF2-addicted lung cancers (Romero et al